Projects

Characterising genotype and phenotype clonal evolution of response to therapy with Artificial Intelligence

The CDS Lab leads this 5 years AIRC-funded MFAG project, where we use Artificial Intelligence to study clonal evolution under therapy, integrating longitudinal bulk and single-cell data of haematological cancers.

Starting year and duration: 2021 (5 years).

Fund: My First AIRC Grant, Associazione Italiana Ricerca sul Cancro (AIRC).

Team:

  • Dr Giulio Caravagna (University of Trieste). Principal Investigator.

  • Luca Vago, MD (San Raffaele Scientific Institute). Collaborator,.

  • Valter Gattei, MD (CRO National Cancer Institute). Collaborator.

  • Dr Giovanni Tonon. (San Raffaele Scientific Institute). Collaborator,.

The EVOverse

The CDS lab and the Sottoriva lab have established EVOverse, a collaborative project between the University of Trieste and Human Technopole, to develop new Artificial Intelligence and population genetics methods to measure clonal evolution from cancer sequencing data.

  • Starting year and duration: 2022 (3 years). PI G Caravagna - A Sottoriva.

  • Fund: Internal.

  • Team:

    • Dr Giulio Caravagna (University of Trieste). Co-Principal Investigator.

    • Dr Andrea Sottoriva (Human Technopole). Co-Principal Investigator.

Single-cell cancer evolution in the clinic

The CDS Lab collaborates to this project to combine cancer evolution modelling, new single-cell approaches and novel microfluidic devices, as well as new data integration techniques, with the aim of providing a definitive single-cell portrait of tumor cells, before and after treatment.

Starting year and duration: 2018 (5 years).

Fund: Accelerator Award, Associazione Italiana Ricerca sul Cancro (AIRC) and Cancer Research UK.

Team:

  • Dr Giovanni Tonon. (San Raffaele Scientific Institute). Principal Investigator,.

  • Dr Andrea Sottoriva (Human Technopole). Co-Principal Investigator.

  • Prof Nicola Valeri (Imperial College). Collaborator.

  • Dr Giulio Caravagna (University of Trieste). Collaborator.

  • Dr Alex Graudenzi (University of Milan-Bicocca) Collaborator.

  • Prof Marco Antoniotti (University of Milan-Bicocca) Collaborator.