Projects
Characterising genotype and phenotype clonal evolution of response to therapy with Artificial Intelligence
The CDS Lab leads this 5 years AIRC-funded MFAG project, where we use Artificial Intelligence to study clonal evolution under therapy, integrating longitudinal bulk and single-cell data of haematological cancers.
Starting year and duration: 2021 (5 years).
Fund: My First AIRC Grant, Associazione Italiana Ricerca sul Cancro (AIRC).
Team:
Dr Giulio Caravagna (University of Trieste). Principal Investigator.
Luca Vago, MD (San Raffaele Scientific Institute). Collaborator,.
Valter Gattei, MD (CRO National Cancer Institute). Collaborator.
Dr Giovanni Tonon. (San Raffaele Scientific Institute). Collaborator,.
Machine Learning algorithms for single-cell and long-reads sequencing
The CDS Lab leads this 2 years MUR-funded PRIN project, where we develop new machine learning algorithms for both single-cell and long-reads sequencing technologies.
Starting year and duration: 2024 (2 years).
Fund: PRIN PNRR 2022, Ministry of University and Research.
Team:
Prof Giulio Caravagna (University of Trieste). Principal Investigator.
Dr Alberto Cazzaniga (Area Science Park). Co-Principal Investigator.
The EVOverse
The CDS lab and the Sottoriva lab have established EVOverse, a collaborative project between the University of Trieste and Human Technopole, to develop new Artificial Intelligence and population genetics methods to measure clonal evolution from cancer sequencing data.
Starting year and duration: 2022 (3 years). PI G Caravagna - A Sottoriva.
Fund: Internal.
Team:
Dr Giulio Caravagna (University of Trieste). Co-Principal Investigator.
Dr Andrea Sottoriva (Human Technopole). Co-Principal Investigator.
Single-cell cancer evolution in the clinic
The CDS Lab collaborates to this project to combine cancer evolution modelling, new single-cell approaches and novel microfluidic devices, as well as new data integration techniques, with the aim of providing a definitive single-cell portrait of tumor cells, before and after treatment.
Starting year and duration: 2018 (5 years).
Fund: Accelerator Award, Associazione Italiana Ricerca sul Cancro (AIRC) and Cancer Research UK.
Team:
Dr Giovanni Tonon. (San Raffaele Scientific Institute). Principal Investigator,.
Dr Andrea Sottoriva (Human Technopole). Co-Principal Investigator.
Prof Nicola Valeri (Imperial College). Collaborator.
Dr Giulio Caravagna (University of Trieste). Collaborator.
Dr Alex Graudenzi (University of Milan-Bicocca) Collaborator.
Prof Marco Antoniotti (University of Milan-Bicocca) Collaborator.
